Premier League Matchday 22 Betting and Fantasy Preview: US TV Schedule, Picks and Match Scripts

Premier League Matchday 22 betting preview

Premier League Matchday 22 lands at a sweet spot for US fans. The timing is friendly, the storylines are sharp, and the fixture list offers a rare mix of reliable favorites, derby chaos and late-slate upside. For bettors and fantasy players, this is a round where understanding game script matters more than chasing names.

Below is a game-by-game betting and fantasy preview, aligned with the US broadcast order on NBC, USA Network and Peacock, and written to help you decide where to play it safe, where to chase ceiling, and where to stay disciplined.

Manchester United vs Manchester City

Saturday – 7:30 AM ET / 4:30 AM PT | NBC & Peacock

The Manchester derby opens the weekend in the premium US slot, and it’s the clearest reminder that rivalry can override form.

Betting view:
City are the more stable side, but derbies punish casual overs. City tend to tighten games once ahead, especially away.

• Safer angles: City moneyline, City team total over

• Higher risk: full-game over goals

Fantasy view:
City attackers remain elite plays even on the road. United assets are best reserved for tournament formats, where volatility is an advantage rather than a problem.

Game script: City control possession; United rely on moments. The first goal shapes everything.

Read more: Manchester Derby: Blood, Pride, and Everything on the Line

Chelsea vs Brentford

Saturday – 10:00 AM ET / 7:00 AM PT | Peacock

This is a classic possession-versus-structure matchup.

Betting view:
Chelsea often dominate territory without blowing teams away. Brentford are comfortable absorbing pressure.

• Lean: Chelsea win and under goals

• Value angle: Brentford + handicap

Fantasy view:
Chelsea defenders and creative midfielders offer steady floors. This is not a game to chase explosive returns.

Game script: Chelsea probe patiently; Brentford wait for counters and set pieces.

Leeds United vs Fulham

Saturday – 10:00 AM ET / 7:00 AM PT | Peacock

This is one of the most overlooked fantasy games of the weekend.

Betting view:
Leeds push tempo; Fulham punish mistakes. That combination often produces goals.

• Lean: Both teams to score

• Live betting: second-half overs

Fantasy view:
Target attackers and wide players. Avoid defenders and goalkeepers.

Game script: Fast, scrappy, momentum-driven. Control changes hands multiple times.

Read more: Premier League Matchday 22: US TV Schedule, Kick-off Times (ET/PT) and Game-by-Game Preview

Liverpool vs Burnley

Saturday – 10:00 AM ET / 7:00 AM PT | Peacock

From a betting and fantasy perspective, this is the most straightforward fixture on the slate.

Betting view:

Liverpool at home against a bottom-half side usually means sustained pressure.

• Strong angles: Liverpool - spread, Liverpool first-half goals

Fantasy view:
Stack Liverpool attackers with confidence. Full-backs also offer assist upside with clean-sheet equity.

Game script: One-way traffic, especially early.

Read more: FACTS about Liverpool F.C: Titles, Managers, Top Players & Trophies

Sunderland vs Crystal Palace

Saturday – 10:00 AM ET / 7:00 AM PT | Peacock

This game won’t trend on social media, but it matters.

Betting view:
Relegation-adjacent fixtures often tighten rather than open.

• Lean: Under total goals

• Alternative: Draw

Fantasy view:
Low ceiling. Defensive midfielders and center-backs have more value than attackers.

Game script: Cautious start, few risks, decisive moment late if it comes at all.

Tottenham Hotspur vs West Ham United

Saturday – 10:00 AM ET / 7:00 AM PT | Peacock

A derby that rarely behaves.

Betting view:
Tottenham’s high line creates opportunity for West Ham’s direct play.

• Lean: Both teams to score

• Higher upside: Spurs win with goals at both ends

Fantasy view:
Spurs attackers carry real ceiling. West Ham defenders can also score via set pieces.

Game script: Emotional, open, and unpredictable. Not one for conservative bets.

Nottingham Forest vs Arsenal

Saturday – 12:30 PM ET / 9:30 AM PT | USA Network & Peacock

This is a textbook title-chase away test.

Betting view:
Arsenal often win these games without dominating the scoreline.

• Safer play: Arsenal moneyline

• Secondary: Arsenal win and under goals

Fantasy view:
Arsenal defenders and holding midfielders gain value. Forest attackers are desperation plays only.

Game script: Arsenal control territory; Forest attack in short, dangerous bursts.

Wolverhampton Wanderers vs Newcastle United

Sunday – 9:00 AM ET / 6:00 AM PT | USA Network & Peacock

This is where discipline beats flair.

Betting view:
Newcastle’s away performances fluctuate. Wolves specialize in dragging games into the margins.

• Lean: Under goals

• Live angle: Wolves draw-no-bet

Fantasy view:
Midfielders and defenders outperform attackers here.

Game script: Tight early, tactical chess rather than end-to-end action.

Aston Villa vs Everton

Sunday – 11:30 AM ET / 8:30 AM PT | NBC & Peacock

NBC’s Sunday showcase pairs ambition with survival instinct.

Betting view:
Villa Park is a genuine edge. Everton’s priority will be containment.

• Lean: Aston Villa win

• Secondary: Everton under team total

Fantasy view:
Villa attackers are strong plays. Villa goalkeeper offers a high-floor option.

Game script: Villa press early; Everton aim to keep it level deep into the match.

Brighton vs Bournemouth

Monday – 3:00 PM ET / 12:00 PM PT | USA Network & Peacock

A perfect late slate closer for US audiences.

Betting view:
Monday games often open up late. Both sides prefer attacking solutions.

• Lean: Over goals

• Live betting: late goal markets

Fantasy view:
Wide attackers and substitutes offer strong late upside.

Game script: Controlled first half, increasing chaos after the hour mark.

Final betting & fantasy takeaways

• Safest stacks: Liverpool, Aston Villa

• Highest volatility: Manchester derby, Spurs–West Ham

• Best under spots: Sunderland–Palace, Wolves–Newcastle

• Best late hammer: Brighton–Bournemouth

• Cash formats: favor home favorites and defenders

• Tournament formats: chase derby chaos and high-tempo games

Matchday 22 rewards patience, structure and selective aggression. Pick your spots, respect game scripts, and let the schedule work for you.