Top 9 Largest Vaccine Companies In The World

The world's top vaccine producers, who produce a variety of vaccines, are expected to drive the fast expansion of the vaccines market globally. The current Covid-19 global pandemic has also had a significant positive effect on this market since it has driven many of the top vaccine manufacturers in the world to concentrate on creating the best vaccine to fight the highly contagious and potentially fatal coronavirus. Because of the fierce competition among vaccine manufacturers who are putting more of an emphasis on the research and development of live vaccines, the global vaccine market is predicted to grow significantly over the next five years.

Vaccinations against illnesses like chickenpox, diphtheria, influenza, meningococcal infection, and hepatitis A are among the frequently given vaccinations. Due to the growing number of diseases that can be prevented with vaccinations, a number of top vaccine manufacturers are investing heavily in the development of adult and pediatric vaccination schedules.

Top 9 Biggest Vaccine Companies in the World

9. Curevac

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A German biopharmaceutical company called CureVac N.V. creates messenger RNA (mRNA)-based therapeutics. The company was founded in 2000 by Ingmar Hoerr (CEO), Steve Pascolo (CSO), Florian von der Mulbe (COO), Günther Jung, and Hans-Georg Rammensee. It has its legal domicile in the Netherlands and its headquarters are in Tübingen, Germany. Around 240 people worked for CureVac in November 2015, and 375 in May 2018.

The company's main priorities are the development of cancer and rare disease treatments as well as vaccines against infectious diseases. Boehringer Ingelheim, Sanofi Pasteur, Johnson & Johnson, Genmab, the Bill & Melinda Gates Foundation, Eli Lilly and Company, GlaxoSmithKline, the Coalition for Epidemic Preparedness Innovations, the International AIDS Vaccine Initiative, and the German government are among the organizations with which CureVac has entered into a number of partnerships.

Total market cap: $19.153 billion

Total revenue: $19.49 million

8. Biontech

Photo: Reuters

German biotechnology company BioNTech SE, short for Biopharmaceutical New Technologies, has its headquarters in Mainz. It creates and produces active immunotherapies for patient-specific disease treatment strategies. It creates messenger ribonucleic acid (mRNA)-based pharmaceutical candidates for use as customized cancer immunotherapies, vaccines against infectious diseases, and protein replacement therapies for uncommon diseases. It also develops engineered cell therapy, new antibodies, and small molecule immunomodulators as cancer treatment options.

In order to establish its own manufacturing process and advance customized mRNA-based cancer immunotherapy into clinical trials, the company has created an mRNA-based human therapeutic for intravenous administration.

In 2020, BioNTech developed the RNA vaccine BNT162b2 for COVID-19 infections, working with Pfizer for testing and logistics. This vaccine has a 95% efficacy rate in preventing confirmed COVID-19 cases that happen at least 7 days after the second dose of the vaccine. The United Kingdom government authorized the temporary use of HMR for BNT162b2 vaccinations within the country on December 2, 2020. It was the first authorized mRNA vaccine ever. A few days later, Switzerland, Canada, and the United States all approved the vaccine on an emergency basis. The coronavirus vaccine developed by BioNTech and Pfizer was approved by the European Commission on December 21, 2020, following the European Medicines Agency's (EMA) highly recommended recommendation.

Total market cap: $29.26 billion

Total revenue: $131.43 million

7. Chongqing Zhifei Biological Products

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In the biological product industry, Chongqing Zhifei Biological Products Co., Ltd., also known as "Zhifei" or "the Company," was founded in 2002. With the help of its almost 3,300 workers, the company generated an operating income of RMB15.19 billion in 2020 on the basis of its RMB1.6 billion registered capital and RMB15.2 billion total assets.Zhifei became the first privately-run vaccine company listed on ChiNext when it was listed in September 2010 on the Shenzhen Stock Exchange (stock code: 300122). Anhui ZhifeiLongcom Biopharmaceutical Co., Ltd. and Beijing ZhifeiLvzhu Biopharmaceutical Co., Ltd. are two of Zhifei's newest high-tech companies. Zhifei has five wholly-owned subsidiaries and one joint-stock subsidiary.

Zhifei is a high-tech biological enterprise that integrates research and development, production, marketing, distribution, and import and export. Its primary business is the production of vaccines for human use, which is one of China's seven strategically important emerging industries with room to grow. Recombinant Novel Coronavirus Vaccine (CHO Cell), Recombinant Mycobacterium Tuberculosis Fusion Protein (EC) (Ekear®), Haemophilus Influenzae Type b Vaccine (XiFeiBei®), Group ACYW135 Meningococcal Polysaccharide Vaccine (Menwayc®), Mycobacterium Vaccae for Injection (Vaccae®), Meningococcal Group A and Group C Polysaccharide Conjugate Vaccine (Mening A Con®), and other independently developed products are among the company's commercially available products. In the interim, Zhifei is the exclusive distributor of Merck Sharp & Dohme (MSD) vaccines, including the 5-valent Rotateq vaccine, the 23-valent Pneumovax 23 vaccine, the HPV4 (Gradasil) vaccine, and the HPV9 (Gradasil 9) vaccine.

Total market cap: $37.52 billion

Total revenue of the company: $1.657 billion

6. Moderna

Photo: BBC

The COVID-19 vaccine developed by Moderna, the Biomedical Advanced Research and Development Authority (BARDA), and the National Institute of Allergy and Infectious Diseases (NIAID) in the United States is known as mRNA-1273. It is used to protect individuals 18 years of age and older from infection with the SARS-CoV-2 virus, which causes COVID-19. It is intended to be used as two intramuscular injections of 0.5 mL each, spaced four weeks apart.

It is an RNA vaccine made up of lipid nanoparticle-encapsulated nucleoside-modified mRNA (modRNA), which codes for the SARS-CoV-2 spike protein.

There are 45 countries where the Moderna COVID-19 vaccine is approved for use, including the US, Canada, the UK, Israel, Singapore, and the European Union.

Phase I clinical trials for Moderna's second COVID-19 vaccine, mRNA-1283, commenced on March 15, 2021.

Total market cap: $44.616 billion

Total revenue: $94.47 million

5. Glaxo Smith Kline

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London, England serves as the corporate headquarters of the multinational pharmaceutical firm GlaxoSmithKline plc (GSK). Founded in 2000 through the combination of Glaxo Wellcome and SmithKline Beecham, GSK ranked sixth globally in terms of pharmaceutical sales as of 2019, behind Pfizer, Novartis, Roche, Sanofi, and Merck & Co. The UK government committed to purchasing 60 million doses of the GSK and Sanofi-developed COVID-19 vaccine in July 2020. It makes use of GSK's pandemic technology and Sanofi's recombinant protein-based technology. Assuming successful trials and regulatory approval, the companies projected that they could produce one billion doses in the first half of 2021. Additionally, the company consented to a $2.1 billion agreement with the US government to manufacture 100 million vaccination doses.

Total market cap: $96.115 billion

Total revenue of the company: $40.832 billion

4. Sanofi

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Based in Paris, France, Sanofi S.A. is a multinational pharmaceutical company that is the fifth-largest in the world based on prescription sales as of 2013. The company was founded in 1973 and became Sanofi-Synthélabo in 1999 after merging with Synthélabo. Both Sanofi-Synthélabo and Aventis, which had each been the result of multiple prior mergers, combined to become Sanofi-Aventis in 2004. In May 2011, it reverted to its previous name, Sanofi. The business is included in the Euro Stoxx 50 index of stock market companies.

Sanofi is primarily involved in the prescription drug market when it comes to research and development, manufacturing, and marketing; however, the company also creates over-the-counter medications. The company's seven main therapeutic areas include internal medicine, thrombosis, diabetes, cardiovascular disease, oncology, and vaccines (through its subsidiary Sanofi Pasteur, it is the world's largest producer of the latter). Sanofi's Dengvaxia dengue vaccine caused controversy in 2017 when some young children who received the vaccination experienced an increase in severe dengue cases. Despite the fact that this new vaccine was not entirely safe, Sanofi's aggressive advertising campaign received criticism, according to the New York Times.

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3. AstraZeneca

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AstraZeneca plc is a multinational pharmaceutical and biotechnology company with Swedish and British ownership. Cambridge, England is home to the Cambridge Biomedical Campus.Products in the oncology, cardiovascular, gastrointestinal, infection, neurological, respiratory, and inflammatory domains are among its portfolio's offerings for serious illnesses. Its contribution to the creation of the Oxford-Astrazeneca COVID-19 vaccine is arguably what made it most famous.

Total market cap:$133.055 billion

Total revenue of the company: $23.565 billion

2. Merck

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Merck & Co. is regarded as one of the biggest pharmaceutical corporations in the world as well as one of the best vaccine manufacturers. George Merck established Merck & Co. in the United States in 1891. Nearly 70,000 people are employed by Merck & Co., the top vaccine manufacturer in the US, which has its headquarters located in New Jersey. Around USD 40 billion is expected to be Merck & Co.'s yearly sales revenue. Some of the company's best-selling vaccines include GARDASIL, RECOMBIVAX HB, RotaTeq, VARIVAX, and ZOSTAVAX.

Total market cap: $210.068 billion

Total revenue of the company: $46.840 billion

1. Pfizer

Photo: Reuters

Pfizer routinely appears in the top 10 global vaccine manufacturers on the most reputable list of vaccine producers. Charles Pfizer and Charles F. Erhart founded Pfizer in 1849, and the company's headquarters are in New York, USA. Almost 98,000 professionals work for Pfizer, which is recognized as one of the leading vaccine companies in the world. Pfizer generates approximately USD 50 billion in revenue annually, and its vaccine brands include NeisVac-C, Mencevax, Nimenrix, Prevnar 13, and Trumenba.

Total market cap: $206.383 billion

Total revenue of the company: $51.750 billion

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