Exploding head syndrome
Exploding head syndrome - Rarest Diseases in the World

1.Exploding head syndrome

This is a syndrome that affects thousands of people around the world with the main manifestation of the feeling that the head explodes while preparing to fall asleep with absolutely no warning signs.

The majority of patients with this syndrome are over the age of 50, but it can also occur in adolescence.

2.Alice in Wonderland Syndrome

Hallucinations, disorientation, loss of sense of self, vision of flying miracles... are the main symptoms of this syndrome. It is common in children and adolescents and can resolve on its own without any special treatment. Some cases have been linked to the use of hallucinogenic drugs, such as amphetamines.

3.Necrotizing fasciitis

Also known as flesh-eating disease, is a rare disease caused by several types of bacteria including group A streptococcus. The disease is characterized by progressive cellulitis. It can cause death within 24 hours and has a mortality rate of over 70%.

4.Menkes disease

The disease is related to genetic abnormalities and tends to be more common in men than in women. Lack of copper in the body is the cause of symptoms such as blurred vision, muscle weakness, convulsions, etc. Treatment is mainly copper supplementation combined with a number of other supportive measures.

5.Cotard delution

This is a delusion in which the sufferer often feels like he is dead. There are quite a few people who have Cotard hallucinations and are treated with medication or dialysis to remove factor 9-Carboxymethoxymethylguanine (CMMG).

6.Tree man syndrome (Epidermodysplasia verruciformis)

'Tree Man' From Bangladesh
'Tree Man' From Bangladesh

The disease is caused by a virus belonging to the human papillomavirus (HPV) family. Lesions are nodules, calloused, bark-like pieces that grow on the face or extremities. The disease is not fatal, but greatly affects the aesthetics and interferes with the daily activities of the patient. There is currently no specific treatment other than cutting off the "twigs" when they grow too long and fast.

7.The Stone Man Syndrome (Fibrodysplasia Ossificans Progressiva)

Gene mutations lead to progressive fibrosis - calcification of the connective tissue of the whole body, making the body stiff and twisted like a living statue. There is currently no effective treatment for this disease.


People with polydactyly have more than 10 fingers or toes, of which the extra toes are usually boneless, only soft tissue (skin, muscle, connective tissue). On average, one out of every 500 babies is born with this defect. Treatment is simply surgical removal of the excess fingers.

9.Darkening of the skin due to silver (argyria)

The disease is caused by long-term exposure to chemical compounds containing silver, which causes the body's skin to turn blue or grayish in color. Laser treatment and the disease can be fatal in some cases.

10.Proteus syndrome

Also known as Wiedemann syndrome, it is characterized by abnormal bone and skin hyperplasia that results in abnormally shaped hands and feet. Treatment methods are still being researched and applied.

11.Werewolf Syndrome

Due to genetic abnormalities, uncontrolled hair growth leads to long, dense hair growth on the whole body or in some parts of the body such as the face, hands, back... This is a very rare disease with About 50 cases have been recorded worldwide.


Porphyria is a genetic or acquired disease characterized by disorders of the production of porphyrins and the heme chain of red blood cells. Abdominal pain, vomiting, neuropsychiatric disorders are common in this disease.

13.Lion face syndrome

The uncontrolled growth of the craniofacial bone makes the patient's face look like a lion's face. The most common comorbid disorder is loss of vision (due to compression of the optic nerve by bone).

14.Progenia (geriatric condition)

Progeria disease is also known as the disease of aging or senility, premature aging. This is a rare disease, according to statistics, there are only about 80 cases in the world currently.

15.Hailey-Hailey Disease

The disease appears after puberty with blistering, inflammatory skin lesions similar to allergies. There is currently no specific treatment.

16.Cronkhite-Canada Syndrome

It is a rare syndrome with manifestations such as loss of taste, intestinal polyps, hair loss, and nail dysplasia. There are about 500 documented cases of this syndrome.

17.Alien Hand Syndrome

Alien Hand Syndrome
Alien Hand Syndrome

Also known as the "alien hand". People with this syndrome have a feeling that they can't control their hands, their hands are not theirs, so they have meaningless and unwanted activities.

18.Lymphatic Filariasis

Because filariasis clogs the lymphatic system, it leads to edematous lower extremities that progress to the size of an elephant's foot, making it difficult for patients to walk. Treat with anthelmintics or surgery as needed.

19.Parry-Romberg syndrome

As a syndrome of unknown cause, the main symptom is muscle, the skin on one side of the patient's face atrophy, causing the face to be concave on one side, unbalanced, and unsightly. There is currently no effective treatment.

20.Lamprey's disease

Perhaps this is the most frightening disease with lesions on the body, especially in the eyes that look like yellow jackfruit spines or like the mouth of an open eel with jagged teeth and a deep throat. hoot. The cause and treatment of the disease are unknown.

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