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What is Dostarlimab: Drug of 100% Cure for Cancer

Vaccine of Mount Sinai Hospital
Cancer Vaccine of Mount Sinai Hospital

Patients with metastatic cancer often have a very low chance of survival. With some types of cancer, the five-year survival rate is just 6%, according to the Mayo Clinic.

Both patients received a vaccine - invented by the famous Mount Sinai Hospital in the US, which quickly dissolves the primary tumor and teaches the body how to hunt down and destroy cancer cells. has spread elsewhere, according to the Daily Mail.

Mrs. Stephanie Gangi, 66 years old, with metastatic breast cancer: Completely cured

After more than 20 years of battling cancer and 12 rounds of devastating surgery and treatment, 66-year-old Stephanie Gangi is ready to give up.

When doctors found a new grapefruit-sized tumor on her adrenal gland last year, she could no longer afford chemotherapy, so she refused further treatment.

So the treating doctor informed her: There is a clinical trial starting and I think it will be very good for you.

Ms. Gangi has been included in a trial in New York (USA) for patients with cancer that has spread throughout the body and is virtually incurable.

Ms. Gangi was injected with the vaccine directly into a large tumor protruding from her breastbone. Within two months, the tumor had completely disappeared, according to the Daily Mail.

Dr Thomas Marron, a member of the inventors team, said it "felt like winning the lottery" when he saw the X-ray showing Mrs. Gangi's adrenal tumor had disappeared.

He added: “That tumor most likely took her life.

Mr. William Morrison, 53 years old, has metastatic blood cancer: Completely cured

Mr. Morrison, 53, from New York (USA), was diagnosed with blood cancer in 2017.

Things took a turn for the worse in 2018, when the cancer became more aggressive and spread to the groin and neck.

He briefly went into remission thanks to chemotherapy in 2019, but relapsed at the start of the pandemic.

Frustrated by this, he agreed to try a new and improved version of the experimental vaccine in 2020. Within six months, the tumors had completely disappeared, according to the Daily Mail.

The vaccine is injected directly into the tumour, meaning that patients who already have an external cancerous mass will be effective.

The vaccine contains a higher dose of a naturally occurring protein that rapidly multiplies the number of dendritic cells in the body - also known as "professor" cells. They destroy tumors and teach T cells in the body to be wary of cancer cells that have spread elsewhere.

The new vaccine is among hundreds of experimental cancer vaccines and drugs that are in the early stages of testing.

The new vaccine has a total of 17 injections into the tumor and an additional 8 into the arm over 6 months.

Cancer vaccine mRNA has the ability to eliminate metastatic melanoma

Cancer vaccines are a controversial topic with a lot of research but very few successful studies.

A new study by scientists from the Tufts School of Engineering may change these results. They have found a way to target cancer in mice with a vaccine so powerful and precise that it clears out melanomas and prevents them from coming back.

Cancer vaccines work similarly to Pfizer and Moderna's COVID-19 vaccines. They deliver mRNA in tiny lipid bubbles that bind to cells in the body, allowing the cells to "read" the mRNA and produce viral antigens, helping to activate the immune system.

Cancer vaccines also deliver mRNA in tiny bubbles, but it encodes antigens in cancer cells, and these bubbles are called lipid nanoparticles to focus on the lymphatic system, thus responding. stronger.

'What we are doing now is developing the next generation of mRNA vaccines using lipid nanoparticle delivery technology, with the ability to target specific organs and tissues,' said Prof.Qiaobing Xu, said the study author.

Development of mRNA cancer vaccine

Targeting the lymphatic system helped this research overcome many of the challenges faced in developing cancer vaccines.

More than 20 mRNAs have been examined in clinical trials, but a large portion of the mRNA ends up in the liver, increasing the risk of inflammation and liver damage. Cancer vaccines would be more effective and longer lasting if more mRNA were directed to the lymphatic system, where B cells, T cells, and other cells of the immune system are located and can fight off cancer cells. cancer.

The lymphatic system plays an important role and is an important target of vaccines because it is where immunity against cancer antigens is acquired.

The researchers revealed that the cancer vaccine was absorbed by about a third of dendritic cells and macrophages. This is significantly higher than the capacity of conventional vaccines.

More dendritic cells and macrophages mean more trained B and T cells and a stronger response against tumors that carry the same antigens found in vaccines.

When treating mice with metastatic melanoma, the lymphatic-targeted vaccine showed significant tumor colonization and a 40% tumor-free and recurrence-free complete response rate over time. long when it is combined with another existing therapy to suppress cancer cells, suppressing an immune response.

All of the mice were in remission and no new tumors were formed when they were subsequently injected with metastatic tumor cells, demonstrating the remarkable effectiveness of the cancer vaccine.

Dr. Jinjin Chen, co-author of the study, said: “Cancer vaccines are always a challenge because tumor antigens are not always the same as those on viruses and bacteria, and tumors can be can actively suppress the immune response. This cancer vaccine induces a much stronger response and is capable of carrying mRNA for both large and small antigens. We hope that it can become a common platform not only for cancer vaccines but also for more effective vaccines against viruses and other pathogens.

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